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Unigraphics NX V4.82 crack and serial number [UNIx]. Download Unigraphics NX V4. 5 Free From Crack Loader with CrackÂ .N-(2-Aminoethyl)piperazine-N’-(2-iminioethyl)amide (WO 95/29189, U.S. Pat. Nos. 5,468,841; 5,510,137; and 5,668,258, the disclosures of which are incorporated herein by reference in their entireties) is an active metabolite of the antidepressant drug maprotiline. The drug (tricyclic antidepressant) is a triarylamine, which is converted to the active metabolite by hydrolysis.
The pharmacokinetics of the parent drug are highly variable. This is probably due to metabolic inter-individual differences. In some cases, patients are not responsive to the drug due to slow hydrolysis or an excessively rapid hydrolysis (drug-drug interaction). In the latter case, better antidepressant efficacy can be achieved by the administration of N-(2-aminoethyl)piperazine-N’-(2-iminioethyl)amide (WO 95/29189, U.S. Pat. No. 5,468,841; 5,510,137; and 5,668,258) or a prodrug thereof.
There has been no commercial success with maprotiline until it was reformulated in 1995 and approved by the FDA in October of 1996 for the treatment of major depression and dysthymia.
N-(2-Aminoethyl)piperazine-N’-(2-iminioethyl)amide is marketed for the treatment of depression under the trade name BROKEN PSYCHE (Wyeth-Ayerst Labs.) by Sandoz International Ltd. The standard formulation is a tablet containing 25 mg of the free acid. The prodrug of maprotiline, N-(2-aminoethyl)piperazine-N’-(2-iminioethyl)amide, has a much longer half-life, and, therefore, is a more efficacious antidepressant than the
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