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Rho-family GTPases coordinate the synthesis of complex cellular structures such as the cytoskeleton and cell-cell junctions by regulating actin dynamics and actomyosin contractility. The Rho family of small GTPases is an important signaling pathway implicated in many biological processes including cell motility, transcriptional regulation, gene silencing, membrane trafficking, cell death, and formation and/or morphogenesis. Rho proteins are regulated by guanine nucleotide exchange factors, GTPase-activating proteins, and GTPase-activating proteins. They function as binary switches by cycling between an inactive GDP-bound state and an active GTP-bound state, which dissociates effectors from their substrates. Rho signaling pathways can act as positive or negative regulators of lung development and growth. In this review, we will discuss the role of Rho signaling in pulmonary development, with particular emphasis on its role as a negative regulator of alveolarization and lung growth.Q:
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