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Pages with no source available will be removed on update.Sex differences in the association between blood pressure and ischemic stroke. Sex differences in the association between blood pressure (BP) and ischemic stroke have been reported, but underlying mechanisms remain unclear. To test the hypothesis that the association between baseline BP and subsequent ischemic stroke differs by sex, we prospectively examined the association between baseline systolic/diastolic BP and the risk of ischemic stroke in a cohort of men and women from the Multi-Ethnic Study of Atherosclerosis (MESA). Incident stroke and myocardial infarction (MI) were identified by regular contact and review of hospital records and self-report, and in-home surveys. We used multivariable logistic regression to determine the association between baseline systolic/diastolic BP and ischemic stroke, MI, and death. Among 6,236 participants, women were more likely to be older, less likely to have diabetes, and more likely to be black than men; systolic BP was higher in women than men; and women were more likely to smoke than men. The average follow-up was 7.9 years. Systolic BP (15 mm Hg) was independently associated with incident ischemic stroke in women, but not in men (odds ratio [OR] = 1.46; 95% confidence interval [CI] = 1.13-1.89), and incident MI in women and men (OR = 1.28; 95% CI = 1.05-1.56 and OR = 1.29; 95% CI = 0.99-1.68, respectively). Similar results were observed in analyses stratified by race/ethnicity, diabetes, smoking, and prevalent cardiovascular disease. We also observed an independent association between baseline diastolic BP and incident MI in women (OR = 1.20; 95% CI = 1.01-1.43) and an association between systolic/diastolic BP and all-cause death in women (OR = 1.12; 95% CI = 1.01-1.24) and men (OR = 1.24; 95% CI = 1.09-1.41). Adjustment for other covariates did not change these associations. Systolic BP was independently associated with incident ischemic stroke and MI in women, but not in men. The absence of an independent association between baseline BP and ischemic a2fa7ad3d0


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