Florence And The Machine – High As Hope (2018) 320 KBPS Utorrent
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Vancomycin has been reported to be effective for Crohn’s disease in the treatment of perianal lesions, but there are few data on its effectiveness and safety in large cohorts of patients. In this study, we have evaluated the use of vancomycin in the treatment of hospitalized and non-hospitalized chronic perianal Crohn’s disease patients in a wide region of Spain. Fifty nine patients were recruited during a six months period. The median (range) age was 41 (18-71) years. Twenty seven patients were surgically treated and 32 had not undergone surgery. A total of 93 lesions were counted, 89% of which (83 lesions) were anal. Crohn’s disease was mild in 30 patients, moderate in 17 and severe in 12. Forty seven patients (81.0%) had isolated perianal disease, 8 (14.4%) had isolated colitis and 3 (5.2%) had isolated intestinal and colitis. Twenty five patients had one or more co-morbidities. Vancomycin was prescribed in 32 patients. The treatment failed in seven patients; 16 patients (47.1%) were candidates for surgery and 10 needed a combined approach. Mean follow up was 28.2 (range 8-60) weeks. Vancomycin was effective in 40.8% of the patients (32% in the simplex treatment group and 55% in the multiplex group; p = 0.09). Six patients had adverse effects, which included drowsiness, diplopia and mild erythema. The most common adverse effect was the development of a rash. Vancomycin is an effective treatment for perianal disease in patients who are surgical candidates.A new era of engagement
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