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The haemodynamic status of critically ill children may change rapidly. An accurate estimation of cardiac preload is important for the adequate treatment of this patients. This study was performed to assess the clinical usefulness of pulmonary capillary wedge pressure (PCWP) and central venous pressure (CVP) in assessing cardiac preload in critically ill infants and children. We conducted a prospective study of 35 consecutive critically ill patients with PCWP or CVP measurements performed at a median (interquartile range) age of 0.4 months (0.2-6.4 months). Preload values were calculated in accordance to the current definitions. Preload values were similar between male and female children (PCWP, 7.8 ± 2.0 vs. 8.0 ± 1.8 mmHg, p=0.45; CVP, 6.2 ± 2.4 vs. 6.3 ± 2.2 mmHg, p=0.71; left ventricular end-diastolic volume (LVEDV) calculated from PCWP, 78.2 ± 15.2 vs. 86.9 ± 22.2 ml/m(2), p=0.14). Preload values were higher in patients with sepsis (PCWP, 9.2 ± 2.5 mmHg, p=0.06; CVP, 7.8 ± 3.3 mmHg, p=0.03; LVEDV calculated from PCWP, 86.0 ± 17.8 ml/m(2), p=0.02) and in patients who required inotropic therapy (PCWP, 10.3 ± 2.4 mmHg, p=0.02; CVP, 8.0 ± 3.2 mmHg, p=0.002). In conclusion, LVEDV estimated from CVP and PCWP in children is similar. Both PCWP and
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