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To investigate the association of three single-nucleotide polymorphisms (SNPs) with depressed patients, 55 Han Chinese subjects were genotyped for the five ADRB3 gene SNPs, including Ile16Asn (A16A) rs1800888, Gln27Glu (G27E) rs1042714, Ala61Gly (A61G) rs1042713, and -1237C>T (IVS4+90G>A) rs1042714. The results were compared with several clinical parameters of these subjects. It is noted that the Ile16Asn (A16A) rs1800888 was significantly associated with depression by comparing with healthy controls in allele model (P=0.005) and dominant model (P=0.043). In depressed subjects, A16A polymorphism carriers had a lower score of the Montgomery Asberg Depression Rating Scale than 16Asn homozygotes (P=0.033). The distribution of A16A genotype frequencies was significantly different between patient and control groups (P=0.038). However, the difference of the frequency distribution of A61G (rs1042713) was not significant between the two groups. We first found that A16A SNP in the ADRB3 gene might be associated with susceptibility to depression.
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